Here are the list of locations I have encountered thus far. Hope this will help you in planning your deck.
| Location(s) | Description |
| Asgard | After turn 4, whoever is winning here draws 2 cards. |
| Atlantis | If you only have one card here, it has +5 Power. |
| Attilan | After turn 3, shuffle your hand into your deck. Draw 3 cards. |
| Avengers Compound | On turn 5, all cards must be played here. |
| Central Park | Add a Squirrel to each location. |
| Cloning Vats | When you play a card here, add a copy to your hand. |
| Crimson Cosmos | Cards that cost 1, 2, or 3 can’t be played here |
| Daily Bugle | Get a copy of a card in your opponent’s hand |
| Danger Room | Cards played here have a 25% chance to be destroyed. |
| Death’s Domain | When you play a card here, destroy it. |
| District X | Replace both decks with 10 random cards. |
| Ego | Ego takes over and plays your cards for you. |
| Elysium | Cards cost 1 less. |
| Fisk Tower | When a card moves here, destroy it. |
| Gamma Lab | After turn 3, transform all cards here into the Hulk. |
| Grand Central |
At the end of turn 5, put a card from each player’s hand here.
|
| Hala |
After turn 4, destroy all cards controlled by the player losing here
|
| Hell’s Kitchen | Draw a 1-Cost card from your deck |
| Hellfire Club | Cards that cost 1 can’t be played here. |
| Isle of Silence | Ongoing effects are disabled here. |
| Kamar-Taj | On Reveal effects happen twice at this location |
| K’un-Lun | When a card moves here, give it +2 Power |
| Limbo | There is a turn 7 this game. |
| Mindscape | At the start of turn 6, swap hands. |
| Mirror Dimension | On turn 4, transform into one of the other locations |
| Mojoworld | Whoever has more cards here gets +100 Power. |
| Monster Island | Add a 9-Power Monster here for each player. |
| Monster Metropolis | The card(s) with the highest Power here get +3 Power |
| Muir Island | After each turn, give cards here +1 Power. |
| Necrosha | Cards here have -2 Power |
| Negative Zone | Cards here have -3 Power. |
| New York | On turn 6, you can move cards to this location. |
| Nidavellir | Cards here have +5 Power. |
| Olympia | Draw 2 cards. |
| Onslaught’s Citadel | Ongoing effects here are doubled |
| Oscorp Tower | After turn 3, all cards here swap sides. |
| Project Pegasus | +5 Energy this turn. |
| Ruin | No effects |
| Sakaar | Put a card from each player’s hand here. |
| Savage Land | Add two Raptors on each side of this location |
| Sewer System | Cards here have – 1 Power. |
| Shadowland | Add a Ninja to each side with -2 Power. |
| Sinister London | When you play a card here, add a copy to another location. |
| Stark Tower | After turn 5, give all cards here +2 Power. |
| Strange Academy | After turn 5, move all cards here to other random locations. |
| Subterranea | Shuffle 5 rocks into each deck. |
| The Bifrost | After turn 4, move all cards one location to the right. |
| The Big House | Cards that cost 4, 5, or 6 can’t be played here. |
| The Hub | Add a random card to each player’s hand. |
| The Ice Box | Give a card in each Player’s hand +1 Cost |
| The Nexus | Your Power here is granted to the other locations as well. |
| The Peak | Each card in your hand swaps its Power and Cost. |
| The Raft | First to fill this draws a 6-cost card. It costs 0. |
| The Space Throne | Only one card can be here for each player. |
| The Superflow | If you have no cards here, +1 energy each turn. |
| The Vault | On turn 6, all cards can’t be played here |
| Tinkerer’s Workshop | – +1 Energy this turn. |
| Titan | 6-Cost cards cost 1 less. |
| TVA | After turn 4, end the game. |
| Wakanda | Cards here cannot be destroyed |
| Wakandan Embassy | Gives +2 Power to cards in players’ hands. |
| Washington D.C. | Cards here with no abilities have +3 Power. |
| Weirdworld | Both players draw from their opponent’s decks. |
| Westview | Turns into a new location at turn 4. |
| Worldship | Destroy the other locations. |
| X-Mansion | After turn 3, add a random card here for each player. |
| Xandar | Card here have +1 Power |
